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The NGF System and its interplay with endocannabinoid signalling, from peripheral sensory terminals to the brain: new targets for the development of next generation drugs for neuropathic pain

CP: Cronic Pain.
Pain that extends beyond the expected period of healing.
EC
Endocannabinoid
Endocannabinoid System
group of neuromodulatory lipids and their receptors in the brain that are involved in a variety of physiological processes including appetite, pain-sensation, mood, and memory; it mediates the psychoactive effects of cannabis.
Epigenetic mechanisms
mechanisms determining changes in gene expression (active versus inactive genes) that do not involve changes to the underlying DNA sequence. Epigenetic modifications can be physiological (e.g. cells differentiation in different cell-types such as skin cells, brain cells, etc. or they can have damaging effects that can result in diseases like cancer. At least three systems including DNA methylation, histone modification and non-coding RNA (ncRNA)-associated gene silencing are currently considered to initiate and sustain epigenetic change.
NGF: Nerve Growth Factor
Small secreted protein that is important for the growth, maintenance, and survival of certain target neurons (nerve cells). It also functions as a signaling molecule
Nociceptive pain
Nociceptive pain is caused by stimulation of peripheral nerve fibers that respond only to stimuli approaching or exceeding harmful intensity (nociceptors), and may be classified according to the mode of noxious stimulation.
NP: Neuropathic Pain
Neuropathic Pain is caused by damage to, malfunction of the nervous system or disease that affects the somatosensory system. It may be associated with abnormal sensations called dysesthesia, and pain from normally non-painful stimuli (allodynia).
OA: Osteoarthritis
Group of mechanical abnormalities involving degradation of joints, including articular cartilage and subchondral bone. Symptoms may include joint pain, tenderness, stiffness, locking, and sometimes an effusion. A variety of causes—hereditary, developmental, metabolic, and mechanical deficits—may initiate processes leading to loss of cartilage. When bone surfaces become less well protected by cartilage, bone may be exposed and damaged. As a result of decreased movement secondary to pain, regional muscles may atrophy, and ligaments may become more lax.
Transgenic
adj. used for organism or cell of one species into which one or more genes of another species have been incorporated.