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The NGF System and its interplay with endocannabinoid signalling, from peripheral sensory terminals to the brain: new targets for the development of next generation drugs for neuropathic pain

Consortium

News and events

    • 01 APR 16
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    Mid-Term Project Summary

    Mid-Term Project Summary

    Project context and the main objectives Chronic pain (CP) is a major unmet medical need and more effective safe drugs are badly needed. Among the most common forms of CP are:  i) neuropathic pain (NP) , associated with nerve injury in the peripheral or central nervous system; and ii) osteoarthritis (OA), a progressive degeneration of

    • April 30, 2015
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    Drug developers reboot anti-NGF pain programmes

    Drug developers reboot anti-NGF pain programmes

    Pfizer, Eli Lilly, Janssen and Regeneron are advancing a promising class of analgesic drugs, hoping to put concerns around autonomic dysfunction and joint destruction behind them. Read the article published on Nature Reviews Drug Discovery 14, 297–298 (2015) Anti-NGF_Pain_Programmes_NatureRevDrugDiscov_2015-1 (1) ( PDF) See also the post: FDA lifts clinical hold on Pfizer/Lilly’s tanezumab

    • 23 SEP 15
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    First prize won by the poster on TrkAKI and OA pain presented at the 13th IASP Research symposium

    First prize won by the poster on TrkAKI and OA pain presented at the 13th IASP Research symposium

    The poster on “Behavioural and immunohistochemical characterisation of TrkA knock-in mice in the monoiodoacetate model of osteoarthritis” presented by the PAINCAGE partners Joao Sousa-Valente and Marzia Malcangio from the King’s College London and Laura Calvo and Juan Carlos Arevalo from the Universidad de Salamanca, won the first prize at the 13th IASP Research symposium:”Bridging the gaps between pain research

    • July 28, 2015
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    About Gender Issues

    About Gender Issues

    Experimenter sex can affect apparent baseline responses in behavioral testing: A recent publication, Robert E Sorge, Loren J Martin, Kelsey A Isbester, Susana G Sotocinal, Sarah Rosen, Alexander H Tuttle, Olfactory exposure to males, including men, causes stress and related analgesia in rodents, Nature Methods 11, 629–632 (2014), has revealed that exposure of mice and

    • 20 JUL 16
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    Article about PAINCAGE on Platinum

    Article about PAINCAGE on Platinum

    At page 73 of the Platinum magazine on the “Research and Innovation” Section, an article about the PAINCAGE project illustrated by the Project Coordinator, prof. Antonino Cattaneo from SNS

    • 19 OCT 15
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    EC FP7 post-grant Open Access Pilot

    EC FP7 post-grant Open Access Pilot

    A pilot action to fund open access peer-reviewed publications from finalized FP7 projects has been launched. This initiative is implemented by the project OpenAIRE2020. The Action is addressed to FP7 project partners who are planning to publish peer-reviewed articles in Open Access journals after the end of the project, who might be able to use the funds made available